Pharma Patent Cliffby readouts.io
Generic and biosimilar makers · US

Who profits from the cliff

The companies lined up to sell copies of the drugs on this tracker, from the FDA's approval lists and the brand owners' own filings. 70 companies across 46 drugs.

CompanyDrugs targeted2025 sales of those brandsDrugs
Zydus 12 $102.1B Entresto, Farxiga, Opsumit, Xtandi, Lynparza, Keytruda, Otezla, Jardiance, Vraylar, Ozempic, Imbruvica, Erleada
Cipla 12 $92.7B Xarelto, Farxiga, Pomalyst, Lynparza, Keytruda, Otezla, Jardiance, Vyndaqel, Descovy, Cabometyx, Calquence, Biktarvy
Sandoz 12 $80.0B Stelara, Prolia, Xgeva, Farxiga, Pomalyst, Januvia, Xtandi, Lynparza, Keytruda, Otezla, Enbrel, Rinvoq
Dr. Reddy's 11 $100.1B Entresto, Prolia, Xgeva, Xarelto, Pomalyst, Keytruda, Jakafi, Darzalex, Cosentyx, Ozempic, Venclexta
Alvotech 11 $77.5B Stelara, Prolia, Xgeva, Xolair, Simponi, Keytruda, Taltz, Tremfya, Kesimpta, Imfinzi, Entyvio
Teva 11 $47.8B Stelara, Prolia, Xgeva, Farxiga, Pomalyst, Januvia, Simponi, Opsumit, Ocrevus, Cabometyx, Entyvio
MSN 10 $41.0B Entresto, Xarelto, Farxiga, Pomalyst, Opsumit, Otezla, Jakafi, Cabometyx, Calquence, Erleada
Celltrion 9 $79.5B Stelara, Prolia, Xgeva, Xolair, Keytruda, Darzalex, Cosentyx, Taltz, Tremfya
Samsung Bioepis 9 $79.0B Stelara, Prolia, Xgeva, Keytruda, Enbrel, Taltz, Dupixent, Tremfya, Entyvio
Apotex 9 $50.4B Xarelto, Pomalyst, Januvia, Opsumit, Xtandi, Jakafi, Vyndaqel, Descovy, Ozempic
Lupin 8 $62.4B Entresto, Xarelto, Farxiga, Xtandi, Eliquis, Descovy, Erleada, Biktarvy
Biocon 8 $39.6B Entresto, Stelara, Prolia, Xgeva, Xarelto, Farxiga, Perjeta, Cabometyx
Sun Pharma 7 $43.2B Pomalyst, Opsumit, Jakafi, Vraylar, Invega Sustenna, Ozempic, Rinvoq
Intas (Accord) 7 $41.8B Stelara, Prolia, Xgeva, Simponi, Eliquis, Invega Sustenna, Rinvoq
Alembic 7 $32.9B Entresto, Xarelto, Farxiga, Opsumit, Lynparza, Jakafi, Venclexta
Aurobindo 6 $35.6B Entresto, Xarelto, Farxiga, Opsumit, Vraylar, Rinvoq
Hetero 6 $29.0B Entresto, Pomalyst, Descovy, Imbruvica, Erleada, Rinvoq
Henlius 5 $56.1B Prolia, Xgeva, Perjeta, Keytruda, Darzalex
Viatris (Mylan) 5 $50.8B Pomalyst, Opsumit, Eliquis, Ozempic, Wegovy
Alkem 5 $26.7B Entresto, Xarelto, Farxiga, Otezla, Jakafi
Hikma 5 $22.0B Stelara, Prolia, Xgeva, Jakafi, Vyndaqel
Amgen 4 $56.3B Stelara, Keytruda, Opdivo, Ocrevus
Macleods 4 $24.1B Entresto, Xarelto, Farxiga, Descovy
Fresenius Kabi 4 $18.6B Stelara, Prolia, Xgeva, Entyvio
Bio-Thera 4 $18.1B Stelara, Simponi, Cosentyx, Nucala
Micro Labs 3 $28.1B Xarelto, Farxiga, Eliquis
Laurus Labs 3 $24.3B Entresto, Opsumit, Biktarvy
Polpharma 3 $19.6B Ocrevus, Tremfya, Entyvio
Torrent 3 $12.3B Entresto, Opsumit, Otezla
Natco 3 $10.0B Lynparza, Descovy, Imbruvica
Amneal 3 $8.8B Prolia, Xgeva, Opsumit
Qilu 2 $35.5B Keytruda, Invega Sustenna
Alvogen 2 $23.3B Ozempic, Imbruvica
Regcon 2 $19.7B Xarelto, Eliquis
Ascent 2 $11.3B Xarelto, Xtandi
Breckenridge 2 $8.0B Xarelto, Pomalyst
Mankind 2 $7.6B Xarelto, Otezla
Eugia 2 $5.8B Pomalyst, Jakafi
BioNTech 1 $31.7B Keytruda
Formycon 1 $31.7B Keytruda
mAbxience 1 $31.7B Keytruda
Rio Biopharmaceuticals 1 $19.3B Ozempic
Chong Kun Dang 1 $17.8B Dupixent
CSPC 1 $17.8B Dupixent
CinnaGen 1 $8.4B Ocrevus
Aizant 1 $8.4B Farxiga
Ajanta 1 $8.4B Farxiga
Inventia 1 $8.4B Farxiga
Crystal Pharmaceutical 1 $7.7B Entresto
Novugen 1 $7.7B Entresto
Somerset Therapeutics 1 $7.7B Entresto
Umedica 1 $7.7B Entresto
Dexcel 1 $6.4B Vyndaqel
Actavis 1 $6.0B Xtandi
Kashiv 1 $5.4B Xolair
Aiping 1 $5.3B Xarelto
Epic Pharma 1 $5.3B Xarelto
ScieGen 1 $5.3B Xarelto
Sunshine Lake 1 $5.3B Xarelto
Taro 1 $5.3B Xarelto
Boan Biotech 1 $4.3B Trulicity
Transpire 1 $3.9B Trelegy
Tolmar 1 $3.8B Invega Sustenna
Organon 1 $3.6B Perjeta
Granules 1 $3.1B Jakafi
Lepu 1 $2.3B Opsumit
Annora 1 $2.3B Otezla
Shilpa 1 $2.3B Otezla
Azurity 1 $2.1B Cabometyx
Handa 1 $2.1B Cabometyx

A company counts as targeting a drug if it holds an FDA approval for a copy, has filed for one, has settled or lost a patent case over one, or has a disclosed development program. Brand sales are what the brands earned in 2025, not what any maker will capture; several makers usually share a market.