Entresto patent expiration

What the date means

Entresto's US exclusivity date is based on generics launched. US generics have already launched, so the loss of exclusivity is under way. It is a small-molecule drug, so copies are generics. Generic launches usually take most of the US volume within months.

Medicare price negotiation

Entresto was selected for the Medicare Drug Price Negotiation Program. Its negotiated Medicare price takes effect in 2026, 53% below its list price. US generics had already launched by then. The discount is measured against list price, before the rebates drugmakers already pay, and applies to Medicare only, so the revenue impact is smaller than the headline number.

What changed for Entresto

1. 22 July 2025US copies launched
   First US generics of Entresto launched

   MSN's generic launched through Novadoz, and Torrent followed two days later. Optum Rx

2. August 2024Medicare price
   First Medicare prices set, including Eliquis, Farxiga, Entresto, Enbrel and Stelara

   From 2026: Farxiga 68%, Enbrel 67%, Stelara 66%, Eliquis 56% and Entresto 53% below list price. CMS

Sources

1. Novartis Q4 2025
2. CMS: negotiated prices for 2026