Pharma Patent Cliffby readouts.io
Loss of exclusivity · Cardiometabolic

Ozempic patent expiration

Ozempic (Novo Nordisk) is expected to face US generic competition from 2032. Novo guides to US compound patent expiry in 2032. Generics launched in India and Canada in 2026 as patents lapsed there. Sales DKK 127.1B.

US loss of exclusivity
2032Company guidance
2025 worldwide sales
≈$19.3BNovo Nordisk
Therapeutic area
Cardiometabolic
Medicare negotiated price
−71%From 2027, vs list price
US competition from
GenericsExclusivity ends earlier outside the US

What the date means

Ozempic's US exclusivity date is based on company guidance. The date comes from the company's own filings or guidance. Secondary patents, new formulations or litigation can still move it. It is a peptide regulated as a drug rather than a biologic, so copies are generics. Peptides are harder to copy than typical pills, so generic uptake can be slower.

Medicare price negotiation

Ozempic was selected for the Medicare Drug Price Negotiation Program. Its negotiated Medicare price takes effect in 2027, 71% below its list price. That is 5 years before US generics can launch, so Medicare revenue comes under pressure first. The discount is measured against list price, before the rebates drugmakers already pay, and applies to Medicare only, so the revenue impact is smaller than the headline number.

What changed for Ozempic

  1. Outside the US
    Generic semaglutide launched in Canada

    Dr. Reddy's launched the first generic in Canada, after generics reached India in the first quarter. US protection runs to 2032. Dr. Reddy's

  2. Medicare price
    Medicare prices set for Ozempic, Pomalyst, Ibrance and Xtandi

    From 2027: Ozempic 71%, Pomalyst 60%, Ibrance 50% and Xtandi 48% below list price. CMS

What's at stake for Novo Nordisk

Novo Nordisk
41%

Ozempic is 41% of Novo Nordisk's 2025 revenue (≈$19.3B of $46.8B). Total sales DKK 309.1B.

Bars show each company's tracked drugs as a share of its total 2025 revenue. Ozempic is highlighted.

Other blockbusters losing US exclusivity in 2032

Sources

  1. Novo AR 2025
  2. Novo Q1 2026 (India generics)
  3. Dr. Reddy's (Canada launch)
  4. CMS: negotiated prices for 2027
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