Which drugs go off patent in 2036?
Three blockbuster drugs with $50.8B in 2025 worldwide sales lose US exclusivity in 2036, led by Mounjaro (Eli Lilly, $23.0B). All three are small-molecule or peptide drugs that go generic.
| Drug | Company | Area | 2025 sales | Date basis | US copies | Medicare price |
|---|---|---|---|---|---|---|
| Mounjaro | Eli Lilly | Cardiometabolic | $23.0B | Company guidance | Filed with the FDA | – |
| Biktarvy | Gilead | Infectious disease | $14.3B | Settlement / court date | Filed with the FDA | 2028 · pending |
| Zepbound | Eli Lilly | Cardiometabolic | $13.5B | Company guidance | Filed with the FDA | – |
Every date here is fixed by a launch, settlement, court ruling or company guidance. Each drug's page has the sources.
| Company | Drugs | 2025 revenue from them | Share of company |
|---|---|---|---|
| Eli Lilly | Mounjaro and Zepbound | $36.5B | 56% |
| Gilead | Biktarvy | $14.3B | 49% |
For shared drugs, each company is credited with the revenue it reports, so nothing is counted twice. Share is of the company's total 2025 revenue.
Generic launches usually take most of a drug's US volume within months. Biktarvy was also selected for Medicare price negotiation, which can cut Medicare revenue before or alongside US copies.
US exclusivity can end earlier or later than these dates if a court ruling, settlement or new patent changes the picture. See what happened to sales after past patent cliffs →