Pharma Patent Cliffby readouts.io
Late-stage pipeline · Infectious disease

Late-stage infectious disease biotechs

$17.1B of 2025 infectious disease blockbuster sales lose US exclusivity by 2037, led by Biktarvy, Descovy. These 3 public biotechs have 3 infectious disease treatments in Phase 3 or filed with the FDA, 2 of them already filed.

Who is losing infectious disease revenue

2025 sales each company reports from tracked infectious disease treatments losing US exclusivity by 2037. Big pharma has spent $9.2B on 1 infectious disease acquisitions since 2023. See the deals →

3 biotechs with late-stage infectious disease treatments

Ionis Pharmaceuticals IONS

Ionis has three approved drugs and two fresh Phase 3 wins, but the hepatitis B functional-cure PDUFA is the single event that rerates the stock

  • Bepirovirsen FiledChronic Hepatitis B · HBV antisense oligonucleotide
Read the thesis on Readouts →

PolyPid PYPD

Phase 3-backed SSI drug racing an approval decision against a thin cash cushion, with Azurity's commercialization deal as the bridge

  • D-PLEX 100 FiledSurgical Site Infection Prevention · locally delivered tetracycline antibiotic
Read the thesis on Readouts →

Invivyd IVVD

LIBERTY Phase 3 met all endpoints, but a going-concern company must now finance a BLA and approval before cash runs out

  • VYD2311 Phase 3Covid-19 · anti-SARS-CoV-2 neutralizing monoclonal antibody
Read the thesis on Readouts →

Filed treatments are listed first. This shows where late-stage treatments are being developed, not which companies will be acquired. Pipeline data and summaries from Readouts as of 29 September 2026; companies already acquired are left out.

Other areas: Oncology · Immunology · Cardiometabolic · Vaccine · Neuroscience · Other areas